Profile Response Detail

Molecular Profile ERBB2 neg ERBB2 pos
Therapy Paclitaxel + RO4929097
Indication/Tumor Type Her2-receptor negative breast cancer
Response Type sensitive
Create By spatt
Update By spatt

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 neg ERBB2 pos Her2-receptor negative breast cancer sensitive Paclitaxel + RO4929097 Preclinical Actionable In a preclinical study, circulating tumor cells (CTC) from patients with ERBB2 (HER2)-negative breast cancer were demonstrated to contain both ERBB2 (HER2)-positive and ERBB2 (HER2)-negative subpopulations, and the combination of RO4929097 and Taxol (paclitaxel) resulted in increased tumor growth inhibition in CTC-derived xenograft models compared to either agent alone (PMID: 27556950). 27556950
PubMed Id Reference Title Details
(27556950) HER2 expression identifies dynamic functional states within circulating breast cancer cells. Full reference...