Molecular Profile | KRAS G12D |
Therapy | Luminespib |
Indication/Tumor Type | colon cancer |
Response Type | sensitive |
Create By | spatt |
Update By | tyin |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References | KRAS G12D | colon cancer | sensitive | Luminespib | Preclinical - Cell culture | Actionable | In a preclinical study, Luminespib (AUY922) inhibited growth of a colon cancer cell line harboring KRAS G12D in culture (PMID: 26832792). | 26832792 |
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PubMed Id | Reference Title | Details |
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(26832792) | Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress. | Full reference... |