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|Molecular Profile||ARID1A loss|
|Therapy||AZD8055 + MK2206|
|Indication/Tumor Type||breast cancer|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ARID1A loss||breast cancer||sensitive||AZD8055 + MK2206||Preclinical - Cell culture||Actionable||In a preclinical study, breast cancer cells with loss of ARID1A demonstrated restored sensitivity to AZD8055 when additionally treated with MK2206 in culture (PMID: 27172896).||27172896|
|PubMed Id||Reference Title||Details|
|(27172896)||Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance.||Full reference...|