Profile Response Detail

Molecular Profile FGFR1 positive
Therapy AZD4547 + Sirolimus
Indication/Tumor Type lung adenocarcinoma
Response Type sensitive
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 positive lung adenocarcinoma sensitive AZD4547 + Sirolimus Preclinical - Cell culture Actionable In a preclinical study, AZD4547 and Rapamune (sirolimus) synergistically inhibited survival of FGFR1-dependent lung adenocarcinoma cells in culture (PMID: 26359452). 26359452
PubMed Id Reference Title Details
(26359452) Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC. Full reference...