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|Profile Treatment Approach Name||CDK4/6 Inhibitor|
|Profile Name||CDKN2A R58fs|
|Drug Class||CDK4/6 Inhibitor 13|
|PubMed Id||Reference Title||Details|
|(24495407)||Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines.||Full reference...|
|(23898052)||PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity.||Full reference...|