Profile Treatment Approach Detail

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Profile Treatment Approach Name CDK4/6 Inhibitor
Profile Name CDKN2A E119*
Drug Class CDK4/6 Inhibitor 9
Therapy

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PubMed Id Reference Title Details
(24495407) Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines. Full reference...
(23898052) PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity. Full reference...