Profile Treatment Approach Detail

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Profile Treatment Approach Name FLT3 Inhibitor
Profile Name CBL del
Drug Class FLT3 Inhibitor 55
Therapy

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PubMed Id Reference Title Details
(25477533) Molecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment. Full reference...
(22990016) Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling. Full reference...
(19276253) CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes. Full reference...