Profile Treatment Approach Detail

Profile Treatment Approach Name JAK2 Inhibitor - ATP competitive
Profile Name MPL W515L
Drug Class JAK2 Inhibitor - ATP competitive 14
Therapy

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PubMed Id Reference Title Details
(17541402) TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations. Full reference...
(18354492) TG101348, a JAK2-selective antagonist, inhibits primary hematopoietic cells derived from myeloproliferative disorder patients with JAK2V617F, MPLW515K or JAK2 exon 12 mutations as well as mutation negative patients. Full reference...