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Authors | JR. Molina, M Protopopova, M Bandi, J Bardenhagen, C Bristow, M Alimova, C Carroll, E Chang, N Feng, J Gay, MG Do, J Greer, S Huang, Y Jiang, M Konopleva, P Matre, Z Kang, G Liu, T McAfoos, P Morlacchi, M Smith, S Sonal, J Theroff, Q Xu, G Draetta et al | ||||||||||||
Title | IACS-010759 is a novel inhibitor of oxidative phosphorylation that selectively targets AML cells by inducing a metabolic catastrophe | ||||||||||||
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URL | http://mct.aacrjournals.org/content/14/12_Supplement_2/LB-A15 | ||||||||||||
Abstract Text | Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr LB-A15 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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IACS-010759 | IACS-010759 | 0 | 2 |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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IACS-010759 | IACS-10759 | IACS-010759 inhibits complex I of the electron transport chain to disrupt energy metabolism, resulting in growth inhibition in tumor cells (PMID: 29892070, PMID: 32295842). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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