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PMID
Authors JR. Molina, M Protopopova, M Bandi, J Bardenhagen, C Bristow, M Alimova, C Carroll, E Chang, N Feng, J Gay, MG Do, J Greer, S Huang, Y Jiang, M Konopleva, P Matre, Z Kang, G Liu, T McAfoos, P Morlacchi, M Smith, S Sonal, J Theroff, Q Xu, G Draetta et al
Title IACS-010759 is a novel inhibitor of oxidative phosphorylation that selectively targets AML cells by inducing a metabolic catastrophe
Journal Mol Cancer Ther
Vol
Issue
Date
URL http://mct.aacrjournals.org/content/14/12_Supplement_2/LB-A15
Abstract Text Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr LB-A15

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
IACS-010759 IACS-010759 1 2
Drug Name Trade Name Synonyms Drug Classes Drug Description
IACS-010759 IACS-10759 IACS-010759 inhibits complex I of the electron transport chain to disrupt energy metabolism, resulting in growth inhibition in tumor cells (PMID: 29934314, PMID: 32295842).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown acute myeloid leukemia not applicable IACS-010759 Preclinical - Pdx & cell culture Actionable In a preclinical study, IACS-010759 inhibited growth of acute myeloid leukemia cells in culture, resulting in prolonged survival in patient-derived xenograft models (Mol Cancer Ther 2015; 14(12 Suppl 2): Abstract nr LB-A15). detail...