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Authors | Michael A. Milhollen, Judi Shi, Tary Traore, Jessica Huck, Darshan Sappal, Jennifer Duffy, Eric Lightcap, Yuko Ishii, Jeff Ciavarri, Paul Fleming, Neil Bence and Marc L. Hyer | ||||||||||||
Title | Abstract A164: The small molecule UAE inhibitor TAK-243 (MLN7243) prevents DNA damage repair and reduces cell viability/tumor growth when combined with radiation, carboplatin and docetaxel | ||||||||||||
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URL | http://mct.aacrjournals.org/content/14/12_Supplement_2/A164 | ||||||||||||
Abstract Text | Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A164. |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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TAK-243 | MLN7243 | TAK-243 (MLN7243) is an inhibitor that selectively targets the ubiquitin activating enzyme, UBA1, which may result in inhibition of ubiquitination related processes such as cell cycle progression, apoptotic regulation, and DNA damage response (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A164, PMID: 28711351). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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