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PMID
Authors Abstract C198: PDK1 inhibitors SNS-229 and SNS-510 cause pathway modulation, apoptosis and tumor regression in hematologic cancer models in addition to solid tumors
Title Abstract C198: PDK1 inhibitors SNS-229 and SNS-510 cause pathway modulation, apoptosis and tumor regression in hematologic cancer models in addition to solid tumors
Journal Vol Issue Date Pages Journal Short Title
URL http://mct.aacrjournals.org/content/14/12_Supplement_2/C198
Abstract Text Mol Cancer Ther December 1 2015 (14) (12 Supplement 2) C198

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
SNS-229 SNS-229 0 0
SNS-510 SNS-510 0 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
SNS-229 PDPK1 Inhibitor 10 SNS-229 binds to and inhibits PDPK1 (PDK1), resulting in reduced downstream signaling, and potentially leading to decreased tumor cell proliferation and tumor growth inhibition (Mol Cancer Ther, Dec 1 2015 (14) (12 Supplement 2) C198).
SNS-510 PDPK1 Inhibitor 10 SNS-510 binds to and inhibits PDPK1 (PDK1), resulting in reduced downstream signaling, and potentially leading to decreased tumor cell proliferation and tumor growth inhibition (Mol Cancer Ther, Dec 1 2015 (14) (12 Supplement 2) C198).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References