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Ref Type
PMID
Authors M.J. Hinner, R.S. Bel Aiba, C. Schlosser, T. Jaquin, A. Allersdorfer, S. Berger, A. Wiedenmann, G. Matschiner, J. Sch ?uler, U. Moebius, C. Rothe, S.A. Olwill
Title Costimulatory T-cell engagement by PRS-343, a CD137 (4-1BB)/HER2 bispecific, leads to tumor growth inhibition and TIL expansion in a humanized mouse model
URL http://www.sciencedirect.com/science/article/pii/S0959804916328945?via%3Dihub
Abstract Text Eur J Cancer, Dec 2016, 69 (Suppl 1): S99, abstract 301

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
PRS-343 PRS-343 0 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
PRS-343 HER2 (ERBB2) Antibody 72 TNFRSF9 Antibody 30 PRS-343 is a bispecific antibody targeting both CD137 (4-1BB) and Erbb2 (Her2), resulting in enhanced anti-tumor immune response against Erbb2 (Her2)-positive tumor cells (Eur J Cancer, Dec 2016, 69 (Suppl. 1): S99, abstract 301, PMID: 31138587).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References