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Authors | M.J. Hinner, R.S. Bel Aiba, C. Schlosser, T. Jaquin, A. Allersdorfer, S. Berger, A. Wiedenmann, G. Matschiner, J. Sch ?uler, U. Moebius, C. Rothe, S.A. Olwill | ||||||||||||
Title | Costimulatory T-cell engagement by PRS-343, a CD137 (4-1BB)/HER2 bispecific, leads to tumor growth inhibition and TIL expansion in a humanized mouse model | ||||||||||||
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URL | http://www.sciencedirect.com/science/article/pii/S0959804916328945?via%3Dihub | ||||||||||||
Abstract Text | Eur J Cancer, Dec 2016, 69 (Suppl 1): S99, abstract 301 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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PRS-343 | HER2 (ERBB2) Antibody 72 TNFRSF9 Antibody 30 | PRS-343 is a bispecific antibody targeting both CD137 (4-1BB) and Erbb2 (Her2), resulting in enhanced anti-tumor immune response against Erbb2 (Her2)-positive tumor cells (Eur J Cancer, Dec 2016, 69 (Suppl. 1): S99, abstract 301, PMID: 31138587). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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