Reference Detail

Ref Type
PMID
Authors Johanna C. Bendell, Chloe Evelyn Atreya, Thierry André, Josep Tabernero, Michael S. Gordon, Rene Bernards, Eric Van Cutsem, Sabine Tejpar, Roger Sidhu, William Y. Go, Alicia Allred, Monica Motwani, Benjamin B. Suttle, Yuehui Wu, Axel Hoos, Keith W. Orford
Title Efficacy and tolerability in an open-label phase I/II study of MEK inhibitor trametinib (T), BRAF inhibitor dabrafenib (D), and anti-EGFR antibody panitumumab (P) in combination in patients (pts) with BRAF V600E mutated colorectal cancer (CRC).
Journal
Vol
Issue
Date
URL http://meetinglibrary.asco.org/content/131642-144
Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E colorectal cancer sensitive Dabrafenib + Panitumumab Phase Ib/II Actionable In a Phase Ib/II trial, treatment with the combination of Vectibix (panitumumab) and Tafinlar (dabrafenib) resulted in stable disease in 7/8 colorectal cancer patients harboring a BRAF V600E mutation (J Clin Oncol 32:5s, 2014 (suppl; abstr 3515)). detail...