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Ref Type
Authors Jo Ishizawa, MD, Kensuke Kojima, Archana Dilip, Vivian R Ruvolo, Bing Z Carter, Joshua E Allen, Sattva S. Neelapu, Timothy J. McDonnell, Mala Kiran Talekar, Wafik S. El-Deiry, Larry W. Kwak, Michael Andreeff
Title ONC201 Exerts p53-Independent Cytotoxicity Through TRAIL and DR5 Induction In Mantle Cell Lymphomas
Journal Blood
Vol 122
Issue 21
Abstract Text


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown mantle cell lymphoma not applicable ONC201 Preclinical - Patient cell culture Actionable In a preclinical study, ONC201 induced apoptosis and decreased viability of mantle cell lymphoma (MCL) cell lines in culture and demonstrated cytotoxicity in primary MCL samples in culture (PMID: 26884599). 26884599 detail...