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Ref Type Journal Article
PMID (27477320)
Authors Yeh I, Tee MK, Botton T, Shain AH, Sparatta AJ, Gagnon A, Vemula SS, Garrido MC, Nakamaru K, Isoyama T, McCalmont TH, LeBoit PE, Bastian BC
Title NTRK3 kinase fusions in Spitz tumours.
Journal Vol Issue Date Pages Journal Short Title
The Journal of pathology 240 3 2016 11 282-290 J Pathol
URL
Abstract Text Oncogenic fusions in TRK family receptor tyrosine kinases have been identified in several cancers and can serve as therapeutic targets. We identified ETV6-NTRK3, MYO5A-NTRK3 and MYH9-NTRK3 fusions in Spitz tumours, and demonstrated that NTRK3 fusions constitutively activate the mitogen-activated protein kinase, phosphoinositide 3-kinase and phospholipase Cγ1 pathways in melanocytes. This signalling was inhibited by DS-6051a, a small-molecule inhibitor of NTRK1/2/3 and ROS1. NTRK3 fusions expand the range of oncogenic kinase fusions in melanocytic neoplasms and offer targets for a small subset of melanomas for which no targeted options currently exist. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
DS-6051a DS-6051a 0 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
DS-6051a ROS1 Inhibitor 20 Trk Receptor Inhibitor (Pan) 31 DS-6051a is the free base form of DS-6051b that inhibits ROS1 and NTRK1/2/3, which may lead to growth inhibition in tumor cells (PMID: 27477320).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References