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Ref Type
Authors Rami Rahal, Michelle Maynard, Wei Hu, Jason Brubaker, Qiongfang Cao, Joseph L. Kim, Michael P. Sheets, Douglas P. Wilson, Kevin J. Wilson, Lucian DiPietro, Paul Fleming, Timothy P. LaBranche, Beni Wolf, Timothy Guzi, Christoph Lengauer and Erica K. Evans
Title BLU-667 is a potent and highly selective RET inhibitor being developed for RET-driven cancers
Journal Mol Cancer Ther
Abstract Text Mol Cancer Ther 2018;17(1 Suppl):Abstract nr B151


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Pralsetinib Pralsetinib 32 5
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C634W thyroid gland medullary carcinoma sensitive Pralsetinib Preclinical - Cell line xenograft Actionable In a preclinical study, Gavreto (pralsetinib) inhibited Ret signaling and proliferation of a medullary thyroid cancer cell line harboring RET C634W in culture, and inhibited tumor growth in xenograft models (PMID: 29657135). detail... 29657135