Reference Detail

Ref Type
PMID
Authors Emiliano Calvo, Victor Moreno, Enriqueta Felip, Giuseppe Curigliano, Daniel Morgensztern, James Greger, Kyounghwa Bae, Christina Lourdes Mayer, Jennifer Marino, Edward F. Attiyeh, Hong Xie, James J. Lee
Title Interim results of a phase 1/2 study of JNJ-63723283, an anti-PD-1 monoclonal antibody, in patients with advanced cancers.
Journal Journal of Clinical Oncology
Vol
Issue
Date
URL http://ascopubs.org/doi/abs/10.1200/JCO.2018.36.5_suppl.58
Abstract Text Journal of Clinical Oncology 36, no. 5_suppl (February 10 2018) 58-58.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Therapy Description
Drug Name Trade Name Synonyms Drug Classes Drug Description
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable JNJ-63723283 Phase Ib/II Actionable In a Phase I/II trial, JNJ-63723283 demonstrated safety and preliminary efficacy, resulted in partial response in 9.4% (3/32) and stable disease in 56.3% (18/32) of patients with advanced solid tumors (Journal of Clinical Oncology 36, no. 5_suppl (February 10 2018) 58-58). detail...