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Ref Type
PMID
Authors IE. Krop, O Jegede, JE. Grilley-Olson, JD Lauring, SR. Hamilton, JA. Zwiebel, S Li, L Rubinstein, A Doyle, DR. Patton, EP. Mitchell, CL. Arteaga, BA. Conley, D Sims, L Harris, AP. Chen, K Flaherty
Title Results from molecular analysis for therapy choice (MATCH) arm I: Taselisib for PIK3CA-mutated tumors.
Journal J Clin Oncol
Vol
Issue
Date
URL https://meetinglibrary.asco.org/record/161610/abstract
Abstract Text J Clin Oncol 36, 2018 (suppl; abstr 101)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA act mut Advanced Solid Tumor conflicting Taselisib Phase II Actionable In a Phase II (MATCH) trial, Taselisib (GDC-0032) treatment resulted in no objective response (0/65) but prolonged stable disease (estimated 6-month progression-free survival rate 27%) in patients with advanced solid tumors harboring PIK3CA activating mutations (J Clin Oncol 36, 2018 (suppl; abstr 101); NCT02465060). detail...