Reference Detail

Ref Type
PMID
Authors Suzanne George, Michael C. Heinrich, Albiruni Ryan Abdul Razak, Ping Chi, Michael S. Gordon, Kristen N. Ganjoo, Margaret von Mehren, Neeta Somaiah, Jonathan C. Trent, Ying Su, Rodrigo Ruiz-Soto, Oliver Rosen, Filip Janku
Title Mutation profile of drug resistant gastrointestinal stromal tumor (GIST) patients (pts) enrolled in the phase 1 study of DCC-2618.
Journal Journal of Clinical Oncology
Vol
Issue
Date
URL http://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.11511
Abstract Text Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 11511-11511

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Therapy Description
Drug Name Trade Name Synonyms Drug Classes Drug Description
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown gastrointestinal stromal tumor not applicable DCC-2618 Phase I Actionable In a Phase I study, DCC-2618 treatment resulted in an overall response rate of 16% (16/99) in patients with drug resistant gastrointestinal stromal tumors, 71% (55/77) of analyzed patients harbored baseline KIT or PDGFRA activating mutations (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 11511-11511; NCT02571036). detail...