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Ref Type
Authors A Diab, NM. Tannir, C Bernatchez, CL. Haymaker, SE Bentebibel, BD. Curti, MKK. Wong, I Gergel, MA Tagliaferri, J Zalevsky, U Hoch, S Aung, M Imperiale, DC. Cho, SS. Tykodi, I Puzanov, HM. Kluger, ME. Hurwitz, P Hwu, M Sznol
Title A phase 1/2 study of a novel IL-2 cytokine, NKTR-214, and nivolumab in patients with select locally advanced or metastatic solid tumors.
Journal Journal of Clinical Oncology
Abstract Text Journal of Clinical Oncology 35, no. 15_suppl


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown melanoma not applicable Nivolumab + NKTR-214 Phase Ib/II Actionable In a Phase I/II trial, NKTR-214 and Opdivo (nivolumab) combination treatment demonstrated safety and preliminary efficacy, resulted in radiographic response in one and complete response in another patient with melanoma (Journal of Clinical Oncology 35, no. 15_suppl; NCT02983045). detail...