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Ref Type
Authors M Favata, K Lasky, Y Lo, P Feldman, J Li, Y Chen, C Stevens, M Ye, H Wang, K Liu, R Wynn, Yanlon Li, J Harris, R Landman, Y Li, X Wang, C He, Y Li, C Xue, W Yao, J Rios-Doria, Z Gao, M Covington, XM Liu, H Koblish and P Scherle
Title Characterization of INCB081776, a potent and selective dual AXL/MER kinase inhibitor
Abstract Text Cancer Res 2018;78(13 Suppl):Abstract nr 3759


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
INCB081776 INCB081776 0 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
INCB081776 INCB-081776 AXL Inhibitor 29 INCB081776 is a dual inhibitor of Axl and Mer that blocks TAM family kinase signaling, which may results in enhanced anti-tumor immunity (Cancer Res 2018;78(13 Suppl):Abstract nr 3759).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References