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Authors | Elizabeth Ruth Plummer, Divyanshu Dua, Nicola Cresti, Aneta Suder, Yvette Drew, Peter Stephens, Marie Foegh, Steen Knudsen, Sharon McGonigle, Barbara Ink, Debashis Sarker | ||||||||||||
Title | First-in-human phase 1 study of the PARP/tankyrase inhibitor 2X-121 (E7449) as monotherapy in patients with advanced solid tumors and validation of a novel drug response predictor (DRP) mRNA biomarker. | ||||||||||||
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URL | https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.2505 | ||||||||||||
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Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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