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Ref Type
PMID
Authors N Rudra-Ganguly, C Lowe, C Virata, M Leavitt, L Jin, B Mendelsohn, J Snyder, H Aviña, C Zhang, DL Russell, M Mattie, PYang, B Randhawa, G Liu, F Malik, M Vest, JD Abad, CC Kemball, R Hubert, S Karki, B Anand, Z An, J Grant, JE Dick, F Doñate et. al.
Title AGS62P1, a Novel Anti-FLT3 Antibody Drug Conjugate, Employing Site Specific Conjugation, Demonstrates Preclinical Anti-Tumor Efficacy in AML Tumor and Patient Derived Xenografts
Journal Blood
Vol
Issue
Date
URL http://www.bloodjournal.org/content/126/23/3806?sso-checked=true
Abstract Text Blood 2015 126(23):3806

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
AGS62P1 AGS62P1 1 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
AGS62P1 FLT3 Antibody 3 AGS62P1 is a human anti-FLT3 antibody in conjugation with a microtubule disrupting agent, which may have anti-tumor activity (Blood 2015 126(23):3806, PMID: 29757653).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 positive acute myeloid leukemia predicted - sensitive AGS62P1 Preclinical - Patient cell culture Actionable In a preclinical study, AGS62P1 inhibited growth of FLT3-positive acute myeloid leukemia cell lines in culture, and led to tumor growth inhibition and regression in patient-derived xenograft (PDX) models (Blood 2015 126(23):3806). detail...