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Ref Type
PMID
Authors K J Harrington J Brody M Ingham J Strauss S Cemerski M Wang A Tse A Khilnani A Marabelle T Golan
Title Preliminary results of the first-in-human (FIH) study of MK-1454, an agonist of stimulator of interferon genes (STING), as monotherapy or in combination with pembrolizumab (pembro) in patients with advanced solid tumors or lymphomas
Journal Ann Oncol
Vol
Issue
Date
URL https://academic.oup.com/annonc/article/29/suppl_8/mdy424.015/5141570
Abstract Text Ann Oncol, Oct 2018, 29 (suppl 8), abstract LBA15

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
MK-1454 MK-1454 0 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
MK-1454 STING1 Agonist 8 MK-1454 is an agonist of the stimulator of interferon genes protein (TMEM173, STING1), that when activated leads to the release of cytokines that stimulate cytotoxic T lymphocytes to enhance the anti-tumor immune response (Ann Oncol, Oct 2018, 29 (suppl 8), abstract LBA15, PMID: 31355488).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable MK-1454 + Pembrolizumab Phase I Actionable In a Phase I trial, MK-1454 in combination with Keytruda (pembrolizumab) resulted in partial response in 24% (6/25) and a disease control rate of 48% (12/25) in patients with advanced solid tumors (Ann Oncol, Oct 2018, 29 (suppl 8), abstract LBA15; NCT03010176). detail...