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Ref Type
PMID
Authors P Nghiem, S Bhatia, E J. Lipson, WH Sharfman, RR Kudchadkar, PA Friedlander, AS Brohl, A Daud, HM. Kluger, SA. Reddy, MA Burgess, BA Hanks, T Olencki, BC. Boulmay, LM Lundgren, N Ramchurren, BH Moreno, E Sharon, MA. Cheever, SL Topalian
Title Durable tumor regression and overall survival (OS) in patients with advanced Merkel cell carcinoma (aMCC) receiving pembrolizumab as first-line therapy.
Journal Journal of Clinical Oncology
Vol
Issue
Date
URL http://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.9506
Abstract Text Journal of Clinical Oncology 36, no. 15_suppl (May 2018) 9506-9506.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Merkel cell carcinoma not applicable Pembrolizumab FDA approved Actionable In a Phase II trial (KEYNOTE-017) that supported FDA approval, Keytruda (pembrolizumab) treatment resulted in a confirmed objective response rate of 50% (21/42, complete response 19%, partial response 31%) in patients with advanced Merkel cell carcinoma naive to systemic therapy (J Clin Oncol 36, no. 15_suppl (May 20 2018) 9506-9506; NCT02267603). detail... detail...