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Authors | Jeeyun Lee, Seung Kim, Sujin Lee, Se Hoon Park, Joon Oh Park, Jeong-Won Lee, Kyoung Mee Kim, Hukeun Lee, Sung Hong, Jung Yong Kim, Song-Jae Lee, Seong-Won Song, Jung Ju Kim, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Do-Hyun Nam | ||||||||||||
Title | First-in-human phase I trial of anti-hepatocyte growth factor (HGF) antibody (YYB101) in refractory solid tumor patients. | ||||||||||||
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URL | http://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.e14501 | ||||||||||||
Abstract Text |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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YYB-101 | YYB101|YYB 101 | HGF Antibody 4 | YYB-101 is a humanized monoclonal antibody that targets HGF, potentially resulting in decreased tumor growth (J Clin Onc. 2018 36:15_suppl, e14501, PMID: 31355133). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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