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Ref Type
Authors M Ciomei, E Ardini, L Gianellini, G Borleri, GT Romero, R Ceruti, W Pastori, N Avanzi, D Casero, P Gnocchi, AL Borgia, F Lussana, A Rambaldi, A Galvani, A Isacchi
Title NMS-P088, a novel FLT3, KIT and CSF1R inhibitor, is a promising clinical candidate for AML and CMML treatment.
Journal Proceedings of the American Association for Cancer Research
Abstract Text Proceedings of the American Association for Cancer Research, Vol 60, Mar 2019, Abstract #1324


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
NMS-P088 NMS-P088 1 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
NMS-P088 NMS-P088 inhibits Flt3, Kit, and Csf1r, thus may have anti-tumor activity in hematological cancers (Proceedings of the American Association for Cancer Research, Vol 60, Mar 2019, Abstract #1324).
Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CSF1R positive chronic myelomonocytic leukemia predicted - sensitive NMS-P088 Preclinical - Patient cell culture Actionable In a preclinical study, NMS-P088 inhibited proliferation of Csf1r-expressing blasts derived from chronic myelomonocytic leukemia patients (Proceedings of the American Association for Cancer Research, Vol 60, Mar 2019, Abstract #1324). detail...