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Ref Type
PMID
Authors Veena Jagannathan, Snezana Milutinovic, Ryan Hansen, Bryan Strouse, Christian Hassig, Eric Brown
Title CDC7 kinase inhibition by SRA141 induces a potentially novel caspase-dependent tumor cell apoptosis associated with altered DNA replication and cell cycle dynamics
URL https://www.abstractsonline.com/pp8/#!/6812/presentation/9267
Abstract Text AACR Annual Meeting 2019, Abstract LB-288

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
SRA141 SRA141 0 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
SRA141 CDK7 Inhibitor 16 SRA141 is a CDK7 inhibitor that inhibits DNA synthesis, which may lead to anti-tumor activity (AACR Annual Meeting 2019, Abstract LB-288).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References