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Authors | Veena Jagannathan, Snezana Milutinovic, Ryan Hansen, Bryan Strouse, Christian Hassig, Eric Brown | ||||||||||||
Title | CDC7 kinase inhibition by SRA141 induces a potentially novel caspase-dependent tumor cell apoptosis associated with altered DNA replication and cell cycle dynamics | ||||||||||||
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URL | https://www.abstractsonline.com/pp8/#!/6812/presentation/9267 | ||||||||||||
Abstract Text | AACR Annual Meeting 2019, Abstract LB-288 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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SRA141 | CDK7 Inhibitor 16 | SRA141 is a CDK7 inhibitor that inhibits DNA synthesis, which may lead to anti-tumor activity (AACR Annual Meeting 2019, Abstract LB-288). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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