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Authors | Zezhou Wang, Peter Dove, David Rosa, Bolette Bossen, Simone Helke, Marilyse Charbonneau, Laura Brinen, Karen Dodge, Gloria H. Y. Lin, Carole Galligan, Natasja N. Viller, Mark Wong, Vivian Lee, Tina Catalano, Robert A. Uger, Malik Slassi, Jeff Winston | ||||||||||||
Title | Preclinical characterization of a novel non-cyclic dinucleotide small molecule STING agonist with potent antitumor activity in mice | ||||||||||||
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URL | https://www.abstractsonline.com/pp8/#!/6812/presentation/5408 | ||||||||||||
Abstract Text | AACR Annual Meeting 2019, Abstract 3854 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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TTI-10001 | TTI 10001|TTI10001 | STING1 Agonist 19 | TTI-10001 is a small molecule agonist of STING1 that may lead to activation of anti-tumor immunity (AACR Annual Meeting 2019, Abstract 3854). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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