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Ref Type
Authors Yosuke Ota, Takeshi Otsubo, Junya Koroki, Yuko Hirose, Erina Koga-Yamakawa, Masashi Murata, Masashi Goto and Yasushi Matsuki
Title Novel intravenous injectable TLR7 agonist, DSP-0509, synergistically enhanced antitumor immune responses in combination with anti-PD-1 antibody
Abstract Text Cancer Res July 1 2018 (78) (13 Supplement) 4726


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
DSP-0509 DSP 0509|DSP0509 DSP-0509 is a small molecule agonist of Toll-like receptor 7 (TLR7), which potentially inhibits tumor growth (Cancer Res July 1 2018 (78) (13 Supplement) 4726).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown colon cancer not applicable DSP-0509 + unspecified PD-1 antibody Preclinical Actionable In a preclinical study, an anti-PD-1 inhibitor combined with DSP-0509 inhibited tumor growth in a syngeneic mouse model of colon cancer (Cancer Res July 1 2018 (78) (13 Supplement) 4726). detail...
Unknown unknown osteosarcoma not applicable DSP-0509 Preclinical Actionable In a preclinical study, DSP-0509 inhibited tumor growth and reduced metastatic lung nodules in a syngeneic mouse model of osteosarcoma (Cancer Res July 1 2018 (78) (13 Supplement) 4726). detail...