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Ref Type
PMID (31694708)
Authors
Title 34th Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2019): part 2 : National Harbor, MD, USA. 10 November 2019.
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Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
ADG116 ADG116 0 2
PY159 PY159 0 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
ADG116 ADG-116|ADG 116 CTLA4 Antibody 29 Immune Checkpoint Inhibitor 147 ADG116 is a human monoclonal antagonistic antibody against CTLA4, which may stimulate anti-tumor immune response (PMID: 31694708).
PY159 PY-159|PY 159 PY159 is a monoclonal antibody that binds to and activates TREM1 on tumor-associated myeloid cells, which may promote anti-tumor immune response (PMID: 31694708).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References