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Ref Type
Authors R De Wit, GS. Kulkarni, EM. Uchio, LEM Krieger, JL. Boormans, M Roumiguie, EA. Singer, DF. Bajorin, AM. Kamat, P Grivas, HK Seo, H Nishiyama, BR. Konety, K Nam, E Kapadia, TL. Frenkl, AV Balar
Title Pembrolizumab (pembro) for patients (pts) with high-risk (HR) non–muscle invasive bladder cancer (NMIBC) unresponsive to Bacillus Calmette-Guerin (BCG): Updated follow-up from KEYNOTE-057.
Journal Journal of Clinical Oncology
Abstract Text Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019) 4530-4530


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown bladder carcinoma in situ not applicable Pembrolizumab FDA approved Actionable In a Phase II trial (KEYNOTE-057) that supported FDA approval, Keytruda (pembrolizumab) treatment demonstrated safety and efficacy, resulted in a 3-month complete response rate of 40.2% (41/102), with a median duration of follow-up of 15.8 months in patients with BCG-unresponsive, high-risk, non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ with or without papillary tumors who are unable or refuse to undergo cystectomy (J Clin Onc 37, no. 15_suppl (May 20, 2019) 4530-4530; NCT02625961). detail... detail...