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PMID
Authors Ming-Chen Yang, Yu-Jung Chen, Chi-Sheng Shia, Hui-Wen Chang, Wan-Fen Li, Cheng-Der Tony Yu and I-Ju Chen
Title Novel Globo H targeting antibody-drug conjugate with binding specificity and anti-tumor efficacy in multiple cancer types
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URL https://cancerres.aacrjournals.org/content/79/13_Supplement/4815
Abstract Text Cancer Res 2019;79(13 Suppl):Abstract nr 4815; https://www.researchgate.net/publication/338079467_eFT226_a_first_in_class_inhibitor_of_eIF4A1_targets_FGFR12_and_HER2_driven_cancers

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
OBI-999 OBI999|OBI 999 OBI-999 is an antibody-drug conjugate comprised of the Globo H antibody OBI-888 linked to monomethyl auristatin E, which delivers the anti-microtubule agent to Globo-H-expressing tumor cells, potentially resulting in decreased tumor growth (Cancer Res 2019;79(13 Suppl):Abstract nr 4815).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown stomach cancer not applicable OBI-999 Preclinical - Cell line xenograft Actionable In a preclinical study, OBI-999 treatment inhibited tumor growth in a Globo H-expressing gastric cancer cell line xenograft model (Cancer Res 2019;79(13 Suppl):Abstract nr 4815). detail...
Unknown unknown breast cancer not applicable OBI-999 Preclinical - Cell line xenograft Actionable In a preclinical study, OBI-999 treatment inhibited tumor growth in a Globo H-expressing breast cancer cell line xenograft model (Cancer Res 2019;79(13 Suppl):Abstract nr 4815). detail...
Unknown unknown lung cancer not applicable OBI-999 Preclinical - Pdx Actionable In a preclinical study, OBI-999 treatment inhibited tumor growth in a Globo H-expressing lung cancer cell line xenograft model and a lung cancer patient-derived xenograft (PDX) model (Cancer Res 2019;79(13 Suppl):Abstract nr 4815). detail...
Unknown unknown pancreatic cancer not applicable OBI-999 Preclinical - Cell line xenograft Actionable In a preclinical study, OBI-999 treatment inhibited tumor growth in a Globo H-expressing pancreatic cancer cell line xenograft model (Cancer Res 2019;79(13 Suppl):Abstract nr 4815). detail...