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Authors | Kuan-Chun Huang, Atsushi Endo, Shannon McGrath, Dinesh Chandra, Jiayi Wu, Dae-Shik Kim, Diana Albu, Christy Ingersoll, Karen Tendyke, Kara Loiacono, Thomas Noland, David Verbel, Chi Zhang, Ming-Hong Hao, Mark Matijevic, Vaishali Dixit, Renee R. Hukkanen, Janna Hutz, John Wang, Frank Fang, Xingfeng Bao, Donna Kolber-Simonds, Muzaffar Akram and Nadeem Sarwar | ||||||||||||
Title | Discovery and characterization of E7766, a novel macrocycle-bridged STING agonist with pan-genotypic and potent antitumor activity through intravesical and intratumoral administration | ||||||||||||
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URL | https://cancerres.aacrjournals.org/content/79/13_Supplement/3269 | ||||||||||||
Abstract Text | Cancer Res 2019;79(13 Suppl):Abstract nr 3269 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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E7766 | E-7766|E 7766 | STING1 Agonist 19 | E7766 is an agonist of STING, which may potentially activate anti-tumor immune response (Cancer Res 2019;79(13 Suppl):Abstract nr 3269). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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