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Ref Type | |
PMID | |
Authors | Mihailo Miljanic, Nisha Holay, Anna Capasso, Todd Triplett, Milad Soleimani, Uma Giri, Carla Van Den Berg and Gail Eckhardt |
Title | Attenuating colorectal cancer cell growth and enhancing immunogenicity through rational combination of MEK and HDAC inhibition |
Journal | Cancer Res |
Vol | 79 |
Issue | 13 Suppl |
Date | |
URL | https://cancerres.aacrjournals.org/content/79/13_Supplement/4753 |
Abstract Text | Cancer Res 2019;79(13 Suppl):Abstract nr 4753 |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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HL-085 | HL085|HL 085 | MEK inhibitor (Pan) 22 | HL-085 is a MEK inhibitor that may inhibit proliferation of tumor cells (Cancer Res 2019;79(13 Suppl):Abstract nr 4753). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Unknown unknown | colorectal cancer | not applicable | HL-085 + OKI-005 | Preclinical - Cell culture | Actionable | In a preclinical study, HL085 and OKI-005 demonstrated synergistic activity in 3 of 6 colorectal cancer cell lines, and increased immunogenicity of tumor cells in culture (Cancer Res 2019;79(13 Suppl):Abstract nr 4753). | detail... |