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Ref Type
PMID
Authors Sylvie Moureau, Craig MacKay, Chiara Saladino, Elizabeth Pohler, Karin Kroboth, Jonathan Hollick, Daniella Zheleva, Sheelagh Frame and David Blake
Title The novel PLK1 inhibitor, CYC140: Identification of pharmacodynamic markers, sensitive target indications and potential combinations
URL https://cancerres.aacrjournals.org/content/77/13_Supplement/4178
Abstract Text Cancer Res 2017;77(13 Suppl):Abstract nr 4178

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
CYC140 CYC140 0 2
Drug Name Trade Name Synonyms Drug Classes Drug Description
CYC140 CYC 140|CYC-140 PLK1 Inhibitor 18 CYC140 is an ATP-competitive inhibitor of Plk1, which may lead to cell cycle arrest and inhibition of tumor cell growth (Cancer Res 2017;77(13 Suppl):Abstract nr 4178).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References