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Ref Type
PMID
Authors James W. Janc, Craig M. Hill, Patrick P. Ng, Andrew N. Hoston, Antonett Madriaga, Trang P. Dao-Pick, Kitman S. Yeung, Ryan Hudson, Anne-Marie Beausoleil, Erin Bradley, Erik Verner, Douglas H. Thamm, Richard A. Miller and Joseph J. Buggy
Title A selective inhibitor of interleukin-2-inducible T-cell kinase (ITK) that inhibits T-cell receptor signaling, promotes Th1 skewing, and achieves objective tumor responses when administered to dogs with T cell lymphomas
Journal Vol Issue Date Pages Journal Short Title
Cancer Res 79 13 Suppl
URL https://cancerres.aacrjournals.org/content/79/13_Supplement/1313
Abstract Text Cancer Res 2019;79(13 Suppl):Abstract nr 1313

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
CPI-818 CPI-818 0 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
CPI-818 CPI818|CPI 818 CPI-818 inhibits IL-2 inducible T-cell kinase (ITK), which may lead to inhibition of TCR signaling and growth of T cells (Cancer Res 2019;79(13 Suppl):Abstract nr 1313).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References