Reference Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Ref Type
PMID
Authors Tongfei Wu, Hillary Millar, Dana Gaffney, Lijs Beke, Geert Mannens, Petra Vinken, Ivan Sommers et al.
Title JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models
URL https://cancerres.aacrjournals.org/content/78/13_Supplement/4859
Abstract Text Cancer Res 2018;78(13 Suppl):Abstract nr 4859

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
JNJ-64619178 JNJ-64619178 0 1
Drug Name Trade Name Synonyms Drug Classes Drug Description
JNJ-64619178 JNJ64619178|JNJ 64619178 PRMT5 Inhibitor 16 JNJ-64619178 is a PRMT5 inhibitor that binds to and inhibits the S-adenosylmethionine (SAM) and substrate-binding regions of the PRMT5/MEP50 complex, potentially reducing dimethylation of target proteins such as SMD1/3 and resulting in tumor growth inhibition (Cancer Res 2018;78(13 Suppl):Abstract nr 4859, PMID: 31312965).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References