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PMID
Authors Nir Kleinmann , Surena Matin , Philip Pierorazio , John Gore , Ahmad Shabsigh , Brian Hu , Karim Chamie , Guy Godoy , Scott Hubosky , Marcelino RIvera , Michael O'Donnell , Marcus Quek , Jay Raman , Douglas Scherr , Joshua Stern , Christopher Weight , Alon Weizer , Michael Woods , Hristos Kaimakliotis , Angela Smith VChapel , Jennifer Linehan , Jonathan Coleman , Mitchell Humphreys , Raymond Pak , David Lifshitz , Michael Verni , Elyse Seltzer , Ifat Klein , Mark Schoenberg , and Seth Lerner
Title NEPHRON-SPARING MANAGEMENT OF LOW GRADE (LG) UTUC WITH UGN-101 (MITOMYCIN GEL) FOR INSTILLATION: THE OLYMPUS TRIAL EXPERIENCE
Journal J Urol.
Vol 201
Issue Supplement 4
Date
URL https://www.auajournals.org/doi/10.1097/01.JU.0000557508.23335.0a
Abstract Text J Urol. 2019 Apr; 201 (Supplement 4): abstract LBA-16

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Mitomycin gel Jelmyto UGN-101 Jelmyto (mitomycin gel) is a prolonged release gel formulation of mitomycin that may have antitumor activity when applied in the upper urinary track (J Urol. 2019 Apr; 201 (Supplement 4): abstract LBA-16). Jelmyto (mitomycin for pyelocalyceal solution) is FDA approved for use in patients with low-grade upper tract urothelial cancer (FDA.gov).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown renal pelvis transitional cell carcinoma not applicable Mitomycin gel FDA approved Actionable In a Phase III trial (OLYMPUS) that supported FDA approval, Jelmyto (mitomycin gel) treatment resulted in a complete response in 60% (41/68) of patients with low-grade upper tract urothelial cancer (J Urol. 2019 Apr; 201 (Supplement 4): abstract LBA-16; NCT02793128). detail...
Unknown unknown ureter transitional cell carcinoma not applicable Mitomycin gel FDA approved Actionable In a Phase III trial (OLYMPUS) that supported FDA approval, Jelmyto (mitomycin gel) treatment resulted in a complete response in 60% (41/68) of patients with low-grade upper tract urothelial cancer (J Urol. 2019 Apr; 201 (Supplement 4): abstract LBA-16; NCT02793128). detail...