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Ref Type Journal Article
PMID (24372276)
Authors Shahda S, O'Neil B
Title GI-4000 in KRAS mutant cancers.
Journal Vol Issue Date Pages Journal Short Title
Expert opinion on investigational drugs 23 2 2014 Feb 273-8 Expert Opin Investig Drugs
URL
Abstract Text Cancer develops mainly as a result of accumulating mutations in genes controlling cell growth regulation. RAS is one of the most commonly mutated genes in cancer. While agents targeting the signaling aspects of RAS have met with some success, resistance to therapy remains a major issue. Another focus of drug development has been to harness the immune system to target cells harboring mutated proteins, which can appear 'foreign' to the immune system. It has been observed that cancer is able to avoid regular immune surveillance through local and systemic mechanisms leading to immune tolerance. One potential way of breaking immune tolerance is through vaccine therapy.The authors review the current but limited available literature on KRAS vaccine therapy. The research reviewed was identified from PubMed and presentations from national oncology meetings related to KRAS vaccines in general and GI-4000 series specifically.While targeting KRAS has proven difficulties, developing novel vaccine approaches such as 'tarmogens' appear to be safe with early efficacy in subset of patients with KRAS mutations. However, further research is crucial to identify this group of patients and develop biomarkers.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References