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PMID
Authors Shuyang He, Joseph Gleason, Nassir Habboubi, Robert Hariri, Xiaokui Zhang
Title HUMAN PLACENTAL HEMATOPOIETIC STEM CELL DERIVED NATURAL KILLER CELLS FOR GLIOBLASTOMA IMMUNOTHERAPY
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URL https://academic.oup.com/neuro-oncology/article-abstract/21/Supplement_6/vi85/5619950?redirectedFrom=fulltext
Abstract Text Neuro-Oncology, Vol. 21, Issue Suppl_6, Nov. 2019, Page vi85, EXTH-16

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
CYNK-001 Taniraleucel|CYNK001|CYNK 001 CYNK-001 (taniraleucel) consists of allogeneic CD56+/CD3- natural killer cells expanded from CD34-positive placental stem cells, which may induce cytotoxicity against tumor cells and potentially demonstrates anti-tumor activity (Neuro-Oncology, Vol. 21, Issue Suppl_6, Nov. 2019, Page vi85, EXTH-16).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown glioblastoma multiforme not applicable CYNK-001 Preclinical - Cell line xenograft Actionable In a preclinical study, treatment with CYNK-001 resulted in tumor reduction in an orthotopic mouse model of glioblastoma multiforme (Neuro-Oncology, Vol. 21, Issue Suppl_6, Nov. 2019, Page vi85, EXTH-16). detail...