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Ref Type
PMID
Authors Chan Whiting, Kim Fischer, Bryan Laffitte, Lisa Rahbaek, Nick Stock, Davorka Messmer, Austin Chen, Traci Olafson, Natalie Nguyen, et al.
Title Dual antagonism of prostaglandin receptors EP2 and EP4 by TPST-1495 suppresses tumor growth and stimulates anti-tumor immunity
URL https://jitc.bmj.com/content/7/Suppl_1/282
Abstract Text Journal for ImmunoTherapy of Cancer 2019;7:282, Abs nr: P311

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
TPST-1495 TPST-1495 0 2
Drug Name Trade Name Synonyms Drug Classes Drug Description
TPST-1495 TPST1495|TPST 1495 TPST-1495 is a dual antagonist that selectively inhibits EP2 and EP4, and reverses Prostaglandin E2 mediated immune suppression, potentially resulting in enhanced antitumor immune response and tumor growth inhibition (Journal for ImmunoTherapy of Cancer 2019;7:282, Abs nr: P311).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References