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Ref Type
PMID
Authors Wei Xu, Yongping Song, Zengjun Li, Shenmiao Yang, Lihong Liu, Yu Hu, Wei Zhang, Jianfeng Zhou, Sujun Gao, Kaiyang Ding, Huilai Zhang, Zunmin Zhu, Shunqing Wang, Bing Xu, Jianda Hu, Ting Liu, Chunyan Ji, Zhongjun Xia, Yan Li, Xin Wang, Zhixin Xu, Renbin Zhao, Bin Zhang, Alan Zhu, Jianyong Li
Title Safety, Tolerability and Efficacy of Orelabrutinib, Once a Day, to Treat Chinese Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Cell Leukemia
Journal Blood
Vol 134
Issue Supplement_1
Date 2019
URL https://ashpublications.org/blood/article/134/Supplement_1/4319/424621/Safety-Tolerability-and-Efficacy-of-Orelabrutinib
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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown CLL/SLL not applicable Orelabrutinib Phase II Actionable In a Phase II trial, treatment with Orelabrutinib (ICP-022) demonstrated safety and resulted in an objective response rate (ORR) of 88.5% (69/78), including 1 complete response, 39 partial responses, and 29 partial responses with lymphocytosis, and a 6 month duration of response of 89.8% in Chinese patients with relapsed or refractory chronic lymphocytic leukemia/small cell leukemia (Blood (2019) 134 (Supplement_1): 4319). detail...