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PMID
Authors Chun-Feng Xin, Sung Eun Kim, Kyoung-Ho Pyo, Ha Ni Jo, Jae Seok Cho, Jae Hwan Kim, Wongeun Lee, Hee Kyu Lee, Jung-Ho Kim, Ho-Juhn Song, Jong Sung Koh, Byoung Chul Cho.
Title SKI-G-801, an AXL kinase inhibitor, blocks metastasis and induces anti-tumor immune responses in various syngeneic cancer models
Journal
Vol
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Date
URL https://cancerres.aacrjournals.org/content/79/13_Supplement/2010
Abstract Text Cancer Res 2019;79(13 Suppl):Abstract nr 2010

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
SKI-G-801 FLT3 kinase inhibitor SKI G-801|SKI G-801|G-801|G-749 HCl Aurkb Inhibitors 20 Aurkc Inhibitors 3 AXL Inhibitor 27 FGFR1 Inhibitor 23 FGFR3 Inhibitor 12 FLT3 Inhibitor 55 MERTK Inhibitor 9 RET Inhibitor 39 VEGFR1 Inhibitor 5 SKI-G-801 is a multi-kinase inhibitor that has activity against wild-type and mutant forms of FLT3, which blocks FLT3 signaling and potentially inhibits proliferation of FLT3-overexpressing tumor cells, and has additional activity against AXL, potentially leading to decreased tumor cell metastasis, as well as MER, RET, VEGFR1, FMS, FGFR1, FGFR3, AURKB, and AURKC (NCI Drug Dictionary; Cancer Res 2019;79(13 Suppl):Abstract nr 2010).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown breast cancer not applicable SKI-G-801 Preclinical Actionable In a preclinical study, SKI-G-801 treatment reduced tumor growth in a syngeneic mouse model of breast cancer (Cancer Res 2019;79(13 Suppl):Abstract nr 2010). detail...
Unknown unknown melanoma not applicable SKI-G-801 Preclinical Actionable In a preclinical study, SKI-G-801 treatment reduced tumor burden in a metastatic mouse model of melanoma (Cancer Res 2019;79(13 Suppl):Abstract nr 2010). detail...
Unknown unknown lung cancer not applicable SKI-G-801 Preclinical Actionable In a preclinical study, SKI-G-801 treatment reduced tumor growth in a syngeneic mouse model of lung cancer (Cancer Res 2019;79(13 Suppl):Abstract nr 2010). detail...