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Ref Type
PMID
Authors Shih-Feng Cho, Liang Lin, Lijie Xing, Kenneth Wen, Tengteng Yu, Phillip A Hsieh, Yuyin Li, Nikhil C. Munshi, Joachim Wahl, Katja Matthes, Kenneth C. Anderson, Tara Chapman-Arvedson, Yu-Tzu Tai
Title AMG 701 Potently Induces Anti-Multiple Myeloma (MM) Functions of T Cells and IMiDs Further Enhance Its Efficacy to Prevent MM Relapse In Vivo
Journal
Vol
Issue
Date
URL https://ashpublications.org/blood/article/134/Supplement_1/135/426044/AMG-701-Potently-Induces-Anti-Multiple-Myeloma-MM
Abstract Text Blood (2019) 134 (Supplement_1): 135

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown multiple myeloma not applicable AMG 701 Preclinical - Patient cell culture Actionable In a preclinical study, AMG 701 treatment induced lysis of cells from patients with relapsed/refractory multiple myeloma in culture, and inhibited tumor growth in a cell line xenograft model reconstituted with human effector T-cells (Blood (2019) 134 (Supplement_1): 135). detail...
Unknown unknown multiple myeloma not applicable AMG 701 + Lenalidomide Preclinical Actionable In a preclinical study, AMG 701 and Revlimid (lenalidomide) combination treatment enhanced tumor growth inhibition and regression in a mouse model of multiple myeloma (Blood (2019) 134 (Supplement_1): 135). detail...