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Ref Type Journal Article
PMID (25674538)
Authors Wang X, Batty KM, Crowe PJ, Goldstein D, Yang JL
Title The Potential of panHER Inhibition in Cancer.
Journal Frontiers in oncology
Vol 5
Issue
Date 2015
URL
Abstract Text Hyper-activation of the HER (erbB) family receptors, HER 1-4, leads to up-regulation of the three vital signaling pathways: mitogen activated protein kinase, phosphoinositide 3-kinase/AKT, and Janus kinase/signal transducer and activator of transcription pathways. Blocking HER1/EGFR has a limited anticancer effect due to either secondary mutation e.g., T790M or by-pass signaling of other HER members. The emergence of an anti-panHER approach to blockade of these pathways as a cancer treatment may provide a solution to this resistance. This review aimed to provide an overview of the HER signaling pathways and their involvement in tumor progression and examine the current progress in panHER inhibition.Recent literature associated with HER signaling pathways and panHER inhibition was reviewed through PubMed and Medline database, followed by critical comparison and analysis.Pre-clinical studies and clinical trials of panHER inhibitors show promising results, and the potential to improve patient outcomes in solid cancers. The use of panHER inhibitors in cancers with HER-family hyper-activation, such as other epithelial cancers and sarcoma, is a new direction to research and has potential in clinical cancer therapy in the future.

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Molecular Profile Treatment Approach
ERBB2 L786V HER inhibitor (Pan)
ERBB2 Q709L HER inhibitor (Pan)
ERBB2 V773A HER inhibitor (Pan)
ERBB2 E321G HER inhibitor (Pan)
ERBB2 R678W HER inhibitor (Pan)
ERBB2 V773L HER inhibitor (Pan)
ERBB2 T862A HER inhibitor (Pan)
ERBB2 G776_V777insVC HER inhibitor (Pan)
ERBB2 C334S HER inhibitor (Pan)
ERBB2 S423R HER inhibitor (Pan)
ERBB2 D769Y HER inhibitor (Pan)
ERBB2 G660D HER inhibitor (Pan)
ERBB2 D821N HER inhibitor (Pan)
ERBB2 A775_G776insYVMA HER inhibitor (Pan)
ERBB2 G660R HER inhibitor (Pan)
ERBB2 H878Y HER inhibitor (Pan)
ERBB2 A440T HER inhibitor (Pan)
ERBB2 over exp HER inhibitor (Pan)
ERBB2 R896C HER inhibitor (Pan)
ERBB2 G778_S779insLPS HER inhibitor (Pan)
ERBB2 E717D HER inhibitor (Pan)
ERBB2 V777L HER inhibitor (Pan)
ERBB2 S656C HER inhibitor (Pan)
ERBB2 V659E HER inhibitor (Pan)
ERBB2 G222C HER inhibitor (Pan)
ERBB2 M774_A775insAYVM HER inhibitor (Pan)
ERBB2 amp HER inhibitor (Pan)
ERBB2 G776delinsIC HER inhibitor (Pan)
ERBB2 R226S HER inhibitor (Pan)
ERBB2 E693K HER inhibitor (Pan)
ERBB2 G776S HER inhibitor (Pan)
ERBB2 L755_T759del HER inhibitor (Pan)
ERBB2 G776_V777insYVMA HER inhibitor (Pan)
ERBB2 T216S HER inhibitor (Pan)
ERBB2 L755S HER inhibitor (Pan)
ERBB2 G778_S779insG HER inhibitor (Pan)
ERBB2 P780_Y781insGSP HER inhibitor (Pan)
ERBB2 exon 20 ins HER inhibitor (Pan)
ERBB2 S779_P780insVGS HER inhibitor (Pan)
ERBB2 T686A HER inhibitor (Pan)
ERBB2 L726F HER inhibitor (Pan)
ERBB2 A771_Y772insAYVM HER inhibitor (Pan)
ERBB2 positive HER inhibitor (Pan)
ERBB2 G778_P780dup HER inhibitor (Pan)
ERBB2 L869R HER inhibitor (Pan)
ERBB2 V777_G778insG HER inhibitor (Pan)
ERBB2 S310F HER inhibitor (Pan)
ERBB2 act mut HER inhibitor (Pan)
ERBB2 C311R HER inhibitor (Pan)
ERBB2 M774delinsWLV HER inhibitor (Pan)
ERBB2 Y772_A775dup HER inhibitor (Pan)
ERBB2 S653C HER inhibitor (Pan)
ERBB2 S310Y HER inhibitor (Pan)
ERBB2 V754M HER inhibitor (Pan)
ERBB2 T798M HER inhibitor (Pan)
ERBB2 G776delinsLC HER inhibitor (Pan)
ERBB2 L841V HER inhibitor (Pan)
ERBB2 R677L HER inhibitor (Pan)
ERBB2 L866M HER inhibitor (Pan)
ERBB2 G776_V777insVGC HER inhibitor (Pan)
ERBB2 N857S HER inhibitor (Pan)
ERBB2 P551L HER inhibitor (Pan)
ERBB2 L768S HER inhibitor (Pan)
ERBB2 Q679L HER inhibitor (Pan)
ERBB2 L755P HER inhibitor (Pan)
ERBB2 G776delinsVC HER inhibitor (Pan)
ERBB2 A775_G776insSVMA HER inhibitor (Pan)
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References