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Ref Type
Authors Burton, Elizabeth, Wong, Bernice, Zhang, Jiazhong, West, Brian, Bollag, Gideon, Habets, Gaston, Galanis, Allison, Nguyen, Hoa, Arowojolu, Omotayo, Rajhowa, Trivikram, Levis, Mark J.
Title The Novel Inhibitor PLX3397 Effectively Inhibits FLT3-Mutant AML
Abstract Text


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 act mut leukemia sensitive Pexidartinib Preclinical - Cell line xenograft Actionable In a preclinical study, PLX3397 inhibited FLT3 autophosphorylation in leukemia cells overexpressing FLT3 or harboring FLT3 activating mutations, and inhibited growth of leukemia cells harboring FLT3-ITD mutations in culture and in cell line xenograft models (ASH Annual Meeting Abstracts 2011 118: 3632). detail...