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Ref Type
PMID
Authors Burton, Elizabeth, Wong, Bernice, Zhang, Jiazhong, West, Brian, Bollag, Gideon, Habets, Gaston, Galanis, Allison, Nguyen, Hoa, Arowojolu, Omotayo, Rajhowa, Trivikram, Levis, Mark J.
Title The Novel Inhibitor PLX3397 Effectively Inhibits FLT3-Mutant AML
Journal ASH Annual Meeting Abstracts 2011 118: 3632
Vol
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Date
URL http://abstracts.hematologylibrary.org/cgi/content/abstract/118/21/3632?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=PLX3397&searchid=1&FIRSTINDEX=0&volume=118&issue=21&resourcetype=HWCIT
Abstract Text

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
SMAD4 dec exp none no effect SMAD4 dec exp indicates decreased expression of the Smad4 protein and/or mRNA. However, the mechanism causing the decreased expression is unspecified.
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 act mut leukemia sensitive Pexidartinib Preclinical - Cell line xenograft Actionable In a preclinical study, PLX3397 inhibited FLT3 autophosphorylation in leukemia cells overexpressing FLT3 or harboring FLT3 activating mutations, and inhibited growth of leukemia cells harboring FLT3-ITD mutations in culture and in cell line xenograft models (ASH Annual Meeting Abstracts 2011 118: 3632). detail...