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Authors | Ying-Shuan E. Lee, Mann-Yan Kuo, Yi-Ting Huang, Yu-Wen Tseng, Yu Jie Lin, Yen His Liu, Shian-Yi Chiou, Li Jung Chen, Y.-Y. Lu, Chih-Hsin Yang, and Pan-Chyr Yang |
Title | Abstract C270: In vitro and in vivo antitumor activity of DCBCI0901, a potent PI3K/mTORC1/mTORC2 inhibitor. |
Journal | doi: 10.1158/1535-7163.TARG-13-C270 |
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URL | http://mct.aacrjournals.org/content/12/11_Supplement/C270.short |
Abstract Text |
Molecular Profile | Treatment Approach |
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Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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DCBCI0901 | mTOR Inhibitor 51 PI3K Inhibitor (Pan) 38 | DCBCI0901 is an inhibitor of PI3K, mTORC1, and mTORC2, which may result in antitumor activity, including inhibition of cell survival, proliferation, and tumor growth (Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C270). |
Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Unknown unknown | prostate cancer | not applicable | DCBCI0901 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, prostate cancer cells treated with DCBCI0901 demonstrated inhibition of cell proliferation in culture and inhibition of tumor growth in cell-line xenograft models (Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C270). | detail... |
Unknown unknown | breast cancer | not applicable | DCBCI0901 | Preclinical - Cell culture | Actionable | In a preclinical study, breast cancer cell lines treated with DCBCI0901 demonstrated inhibition of cell proliferation in culture (Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C270). | detail... |
Unknown unknown | Advanced Solid Tumor | not applicable | DCBCI0901 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, DCBCI0901 inhibited PI3K and mTOR activation and inhibited growth of several human tumor cell lines in culture and in xenograft models (Mol Cancer Ther November 2013 12; C270). | detail... |
Unknown unknown | leukemia | not applicable | DCBCI0901 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, DCBCI0901 inhibited tumor growth greater than 65% in a leukemia cell line xenograft model (Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C270). | detail... |
Unknown unknown | lung non-small cell carcinoma | not applicable | DCBCI0901 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, non-small cell lung carcinoma cells treated with DCBCI0901 demonstrated inhibition of cell proliferation in culture and inhibition of tumor growth in cell-line xenograft models (Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C270). | detail... |