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PMID
Authors Ryan Blackwell, Karyn Bouhana, Shannon Winski, Patrice Lee, Jim Winkler, Duncan Walker, and Jennifer Garrus
Title Abstract 3610: Pan-ErbB inhibition by ARRY-334543 is superior to selective ErbB inhibition in a preclinical model that signals through multiple ErbB receptors
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URL http://cancerres.aacrjournals.org/content/70/8_Supplement/3610.short
Abstract Text Cancer Res April 15, 2010 70:3610; doi:10.1158/1538-7445.AM10-3610

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 over exp stomach cancer sensitive Tucatinib Preclinical - Cell culture Actionable In a preclinical study, Tukysa (tucatinib) inhibited proliferation of an ERBB2 (HER2) over expressing gastric cancer cell line in culture (Cancer Res April 15, 2010 70:3610). detail...