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Ref Type
Authors Ran Wu, Sheng Guo, Jie Cai, Xuesong Huang, Jie Yang, Jean-Pierre Wery and Henry Qi-xiang Li
Title Biomarker Predictive Ibrutinib Response Using Profiled ABC-DLBCL Patient Derived Xenografts
Abstract Text ASH 75th Annual Meeting, 2015, abstract #2759


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MYD88 L265P non-Hodgkin lymphoma no benefit Ibrutinib Preclinical - Pdx Actionable In a preclinical study, a non-Hodgkin lymphoma (NHL) patient derived xenograft (PDX) model harboring both CD79B Y197N and MYD88 L265P demonstrated sensitivity to Ibruvica (ibrutinib) while an NHL patient derived xenograft (PDX) model harboring only MYD88 L265P did not respond to Ibruvica (ibrutinib) (ASH 57th Annual Meeting, 2015, abstract #2759). detail...